about us
Our group focuses on the rational design and preparation of natural product and small-molecule drug analogues via semi- and diverted total synthesis for both phenotypic and target-based screening to provide the knowledge in structure-activity relationship for drug discovery, aided by various biological and computational studies provided by our collaborators.
One of our key research areas focuses on the discovery of new anti-cancer and anti-Alzheimer's agents such as the diverted total synthesis of melodorinol, flavone, and benzofuropyridines derivatives, and the semi-synthesis of furocoumarin and metformin derivatives to improve their cytotoxicities against various cancer cell lines, to improve the binding towards key enzyme targets of both diseases.
Moreover, we are interested in drugs for tropical diseases such as anti-viral, anti-parasitic, anti-bacterial and anti-fungal drugs; for example, synthesis of novel fluorinated rhodacyanine analogues for potent anti-leishmanial agents, primaquine drug conjugates for anti-malarial agents, novel alkyl quinolone derivatives for anti-bacterial agents, and the screening of novel flavone derivatives as potential drugs against dengue and Covid-19.
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