TKlab-ChemCU

Drug Discovery and Medicinal Chemistry

Asst. Prof. Dr. Tanatorn Khotavivattana
Center of Excellence in Natural Products Chemistry
Department of Chemistry, Faculty of Science, Chulalongkorn University
tanatorn.k@chula.ac.th

Our group focuses on the rational design and preparation of natural product and small-molecule drug analogues via semi- and diverted total synthesis for both phenotypic and target-based screening to provide the knowledge in structure-activity relationship for drug discovery, aided by various biological and computational studies provided by our collaborators.

One of our key research areas focuses on the discovery of new anti-cancer and anti-Alzheimer's agents such as the diverted total synthesis of melodorinol, flavone, and benzofuropyridines derivatives, and the semi-synthesis of furocoumarin and metformin derivatives to improve their cytotoxicities against various cancer cell lines, to improve the binding towards key enzyme targets of both diseases.

Moreover, we are interested in drugs for tropical diseases such as anti-viral, anti-parasitic, anti-bacterial and anti-fungal drugs; for example, synthesis of novel fluorinated rhodacyanine analogues for potent anti-leishmanial agents, primaquine drug conjugates for anti-malarial agents, novel alkyl quinolone derivatives for anti-bacterial agents, and the screening of novel flavone derivatives as potential drugs against dengue and Covid-19.

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Center of Excellence in Natural Products Chemistry

2017 – present Website: https://cenp-chemcu.org/

Research Unit of Metabolic Bone Disease

2018 – present

Design, Synthesis, and Biological Evaluation of Darunavir Analogs as HIV-1 Protease Inhibitors

ACS Bio & Med Chem Au, 2024, 4, 242-256.

TKlab-ChemCU

Drug Discovery and Medicinal Chemistry

about us

Research Unit

Center of Excellence in Natural Products Chemistry

Research Unit of Metabolic Bone Disease

Publications

Design, Synthesis, and Biological Evaluation of Darunavir Analogs as HIV-1 Protease Inhibitors

A facile one-pot iodine-mediated synthesis of cannabinol and derivatives, and their intestinal epithelial barrier protective effect

FMO‑Guided Design of Darunavir Analogs as HIV‑1 Protease Inhibitors

Machine Learning-Guided Design of Potent Darunavir Analogs Targeting HIV-1 Proteases: A Computational Approach for Antiretroviral Drug Discovery

The 8-Bromobaicalein Alleviated Chikungunya-Induced Musculoskeletal Inflammation and Reduced the Viral Load in Healthy Adult Mice

Synthesis of Flavones through NaI-Mediated Electrochemical Cyclization of Chalcones

Design, Synthesis, In Vitro, In Silico, and SAR Studies of Flavone Analogs towards Anti-Dengue Activity

Novel Psoralen Derivatives as Anti‑Breast Cancer Agents and Their Light‑Activated Cytotoxicity against HER2 Positive Breast Cancer Cells

Assay Development and Identification of the First Plasmodium falciparum 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors

Alkyne-Tagged Apigenin, a Chemical Tool to Navigate Potential Targets of Flavonoid Anti-Dengue Leads

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents

Biguanide-Based Synthesis of 1,3,5-Triazine Derivatives with Anticancer Activity and 1,3,5-Triazine Incorporated Calcium Citrate Nanoparticles

Synthesis and Antimicrobial Activity of Novel 4-Hydroxy-2-quinolone Analogs

Bioassay‐Guided Fractionation, Chemical Compositions and Antibacterial Activity of Extracts from Rhizomes of Globba schomburgkii Hook.f.

Feeding Cells with a Novel “Trojan” Carrier: Citrate Nanoparticles

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic hemodialysis patients

Volatile Chemical Composition, Antibacterial and Antifungal Activities of Extracts from Different Parts of Globba schomburgkii Hook. f.

Synthesis of peroxy-functionalized magnetic mesoporous silica for epoxidation of vinyl acetate

Diverted total synthesis of melodorinol analogues and evaluation of their cytotoxicity

Grants

Fundamental Fund 66

Asahi Overseas Research Grants 2021

Research Grant for New Scholar 64

Grants for Development of New Faculty Staff Year 2&3

Ratchadaphiseksomphot Endowment Fund 63

The 26th Science and Technology Research Grant 2019

Research Grant for New Scholar 62

Ratchadaphiseksomphot Endowment Fund 62

Chair Professor Grants

Grants for Development of New Faculty Staff Year 1

Members

Dr. Tanatorn Khotavivattana (Plum)

Viny Alfiyah (Win)

Dini Aulia

Akeanan Sroithongmoon (Tle)

Thitirat Narod (Mild)

Choosak Jaroenrit (Hem)

Alumni

Muhammad Asad Ur Rehman (Leo)

Tharuedee Udomthanapaiboon (Lukplub)

Phuri Poprom (Turbo)

Mongkonkorn Thanakorncharoenwit (Fluke)

Gbenga Olorunmodimu (Micheal)

Patcharaporn Supakijjanusorn (Grace)

Adediji Ayomide Olamide (AY)

Reymark Ereje (Marky)

Apinya Patigo (Meen)

Chiphada Akerungruengkit (Mew)

Thamonwan Chokmahasarn (Mile)

Somruedee Jansongsaeng (Mai)

Monnaya Chalermnon (Aim)

Naruemon Suekaew (SomO)

Thitiya Lasing (Joy)

Kittipat Kulkraisri (Gregor)

Alongkorn Janjamratsaeng (Mek)

Apirak Kunanopparat (Ryo)

Wishulada Injumpa (GGame)

Pitchakorn Jungsanguansit (Fame)

Gallery

Aj. Plum gave a talk in the topic of "Fluorination in Drug Discovery"

Aj. Plum has been promoted to "Associate Professor"

"Young Researcher Award 2024" to Aj. Plum

Michael's Poster Presentation at PACCON 2024

Grace received Scholarship

Marky received "Best Presentation" award

Grace received "Best Oral Presentation" award

รายการทันโลกวิทยาศาสตร์

ยาต้านไวรัสโรคไข้เลือดออก จากสารผลิตภัณฑ์ธรรมชาติ

Marky gave Oral and Rapid Fire talks

AY received Best Poster Prize

Guest Speaker at Chulabhorn Graduate Institute

Lab Trip 2022